9 Essential Questions about Your Body’s Endocannabinoid System


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If you’re unfamiliar with the endocannabinoid system (ECS), you are in for a mind-blowing learning experience.

The ECS is this amazing network of cell-level receptors positioned throughout your entire body.

It’s one of the most abundant protein receptors in the brain, and you can also find these cannabinoid receptors in your organs, your skin, your bones, and connective tissues.

Also found throughout your body are the cannabinoid receptors’ counterpart: endocannabinoids. These cannabinoids produced by your body bind with the CB receptors to complete a neurotransmission process that affects almost every part of your body.

The goal, however, is always the same: to achieve homeostasis or balance in nearly every one of your metabolic processes.

Dr. Dustin Sulak describes the ECS as “perhaps the most important physiologic system involved in establishing and maintaining human health.”

Cannabis, by the way, just happens to be nature’s perfect supplement for this crucial system in our bodies.

The more you learn about the ECS, the more you’ll understand why cannabis can treat so many different illnesses.

Watch cannabis expert Mara Gordon discuss the ECS during CHS 2016:

Here are 9 key questions and answers about the ECS to help you get a better understanding.

#1) Which metabolic processes does the ECS help regulate?

As Dr. Sunil Aggarwal pointed out during CHS 2016, the ECS plays a role in processes such as:

  • Mood regulation
  • Appetite
  • Memory
  • Inflammation
  • Pain perception
  • Muscle tone and movement
  • Extinction of traumatic memory
  • Protection of nerves and brain tissue
  • Bone growth
  • Tumor regulation
  • Baby breast-feeding reward
  • Stress management
  • Eye pressure
  • Gastrointestinal motility
  • Seizure activity
  • And many others

When I interviewed Dr. Raphael Mechoulam in 2016, one of the scientists who helped discover the ECS, he shared with me his suspicions that it may even play a role in defining our personalities!

One place in your body where you DON’T have CB receptors is your brain stem, which is why it’s impossible to have a lethal overdose on cannabis.

#2) Why is the ECS named after cannabis?

Cannabis plant
Anybody who still demonizes this plant needs to be educated on the facts.

When scientists first discovered the ECS in the late 1980s, they did so by observing how THC interacted with the body. They saw how the THC molecule was binding with all these receptors in our brain and soon discovered them throughout most of the body.

This led to the discovery of the endocannabinoids, and now we’re learning more about things like endocannabinoid deficiency and other dysfunctions susceptible in the ECS, and how we can use cannabis to help keep the system healthy.

Simply put, we may not have ever discovered this all-important system in our bodies if it weren’t for cannabis.

#3) What does the ECS actually look like?

The ECS is a cellular-level system, which means you can’t see it with the naked eye.

However, if you were to shrink yourself down to molecular size, you’d see that these protein-based cannabinoid receptors are positioned on the very surface of your cells.

Martin Lee of Project CBD does a great job at describing this in his article about the discovery of the ECS, writing how the cannabinoid receptor “consists of 472 amino acids strung together in a crumpled chain that squiggles back and forth across the cell membrane seven times.”

He continues: “Cannabinoid receptors function as subtle sensing devices, tiny vibrating scanners perpetually primed to pick up biochemical cues that flow through fluids surrounding each cell.”

#4) How do cannabinoids interact with the ECS exactly?

Endocannabinoid system diagram
Missing from this graphic: CBD, which has valuable, indirect effects on the ECS.

Cannabinoids act both directly and indirectly on our cannabinoid receptors (also known as CB receptors).

Some cannabinoids can act as agonists, which means they activate certain receptors. Other cannabinoids can act as antagonists – essentially deactivating receptors.

If the ECS is not functioning properly, the right combination and amount of cannabinoids can help supplement the system and get all those signals to work properly.

More of this signal, less of that signal. Your body is an ongoing symphony and the ECS is the conductor!

#5) Do terpenes also interact with the ECS?

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Generally terpenes do not interact with the ECS but rather other parts of your physiology. The exception would be beta-caryophyllene (also found in black pepper).

Researchers have found this terpene actually binds with CB2 receptors, acting as an agonist or activator.

This finding would suggest that the terpene beta-caryophyllene is actually a cannabinoid!

#6) Is consuming too much cannabis harmful to your endocannabinoid system?

Cannabis leaves and buds
We all have our own ideal dosage range for cannabis. A lot of people are overconsuming and don’t even know it.